Current Issue Subscriptions
Back Issues Advertising
More Information Classified Ads
For Authors Continuing Education
 
Vol. 75, No. 5
 
ISSN: 1488-2159
 
June 2009

 

Tissue Engineering Scaffolds for the Regeneration of Craniofacial Bone

FULL TEXT

• Wailan D. Chan, MESc •
• Hiran Perinpanayagam, DDS, PhD •
• Harvey A. Goldberg, PhD •
• Graeme K. Hunter, PhD •
• S. Jeffrey Dixon, DDS, PhD •
• Gildo C. Santos Jr., DDS, PhD •
• Amin S. Rizkalla, PhD, PEng •

A b s t r a c t

Current strategies for skeletal regeneration involve the use of autogenous and allogenic bone grafts that may not always be available or safe to use. One alternative is to develop materials for use as scaffolds for the tissue engineering of bone. We created architecturally nanofibrous scaffolds using the electrospinning technique. These calcium phosphate- based materials are porous, have a large surface-area-to-volume ratio and can be used to deliver drugs, biologics or cells for tissue engineering applications. Bone-matrix proteins were also conjugated to the surface of a polymer network of polycaprolactone and poly(2-hydroxyethyl methacrylate) to create a material with enhanced cellular responses. This biomimetic strategy resulted in favourable cell-surface interactions that will likely enhance bone-matrix synthesis and regeneration. These collective advancements enable the development of innovative scaffolds for applications in tissue engineering and bone regeneration.

 


 
Reply to this article | View replies [0]

Full text provided in PDF format


 

Mission Statement & Editor's Message | Multimedia Centre | Readership Survey
Contact the Editor | Franηais

www.cda-adc.ca