Current Issue Subscriptions
Back Issues Advertising
More Information Classified Ads
For Authors Continuing Education
Vol. 75, No. 5
ISSN: 1488-2159
June 2009


Cellular Response to Mineral Trioxide Aggregate Root-End Filling Materials


• Hiran Perinpanayagam, DDS, PhD •

A b s t r a c t

Endodontic surgical procedures involve the use of a root-end filling material to provide an apical seal and to facilitate the repair and regeneration of periradicular tissues. Whereas earlier studies typically evaluated the cytotoxicity of these materials, contemporary research has focused on their capacity to support a favourable cellular response. In vitro tissue culture techniques have demonstrated interactions at the cell surface that may be conducive to periapical healing. Recent research with osteoblasts has confirmed their affinity for novel endodontic mineral trioxide aggregate (MTA) materials, with evidence of cell attachment and synthesis of bone matrix. This article reviews the current state of knowledge about MTA as a root-end filling material, with particular emphasis on cellular response to MTA materials.


Reply to this article | View replies [0]

Full text provided in PDF format


Mission Statement & Editor's Message | Multimedia Centre | Readership Survey
Contact the Editor | Français