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Vol. 73, No. 9
ISSN: 1488-2159
November 2007


Albright's Hereditary Osteodystrophy with Extensive Heterotopic Ossification of the Oral and Maxillofacial Region: How Fetuin Research May Help a Seemingly Impossible Condition


• Marc G. DuVal, DDS •
• Sarah Davidson, DDS •
• Andrew Ho, DDS •
• Rachale Cohen, DDS •
• Michael Park, DDS •
• Somayeh Nourian, DDS •
• Gerald Baker, DDS, MS, FRCD(C) •
• George K.B. Sαndor , MD, DDS, PhD, FRCD(C), FRCSC, FACS •

A b s t r a c t

Albright's hereditary osteodystrophy (AHO) is a complex genetic disorder characterized by brachydactyly, gonadotropin resistance, hypothyroidism, pseudohypoparathyroid syndrome and heterotopic ossification. Heterotopic ossification rarely occurs in the maxillofacial region. In this article, we present such a case, describe the etiology, characteristics and treatment of AHO and suggest a potential role of an inhibitor of bone formation such as fetuin in preventing recurrence of aberrant ossification.


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