|   | Patient
  or problem | Intervention (treatment, test,
  prognostic factor, cause, etc.) | Outcome(s) | 
|   |   |   |   | |
| Tips
  for building a question | Starting
  with your patient, ask “How would I describe a group of patients similar to
  mine?” Be precise, yet brief. | Ask,
  “Which main intervention am I considering?” Be specific. | Ask,
  “What is the main alternative to compare with the intervention?”  Again, be specific. | Ask,
  “What can I hope to accomplish?” or “What could this exposure really affect?” Be specific. | 
Adapted
from Sackett and others,6 with permission.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
| Type
  of question | Patient
  or problem | Intervention
  (treatment, test, prognostic factor, cause, etc.) | Comparison
  (if any) | Outcome(s) | 
|   | ||||
| Therapy | “For
  children with posterior crossbite in the primary dentition…  | …will
  occlusal grinding to remove premature contacts,… | …when
  compared to no intervention,… | …prevent
  posterior crossbite in the permanent dentition?” | 
|   | ||||
| Diagnostic | “In
  patients with undiagnosed oral lesions… | …can
  a toluidine blue mouth rinse,… | …when
  compared to an oral biopsy,… | …effectively
  detect oral cancer and precancer?” | 
|   | ||||
| Prognosis | “For
  patients with osseointegrated implants… | …who
  smoke,… | …compared
  to patients who do not smoke,… | …what
  is the proportion of implants lost at 10 years?” | 
|   | ||||
| Causation | “For
  my pregnant dental assistant… | …exposed
  regularly to the use of nitrous oxide for patient sedation… |   | …what
  is the risk of harm to her unborn baby?” | 
Adapted
from Sackett and others,6 with permission.